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Thermo-Mechanical Action

Tixel is the next generation of energy-based devices. The world's first Thermo Mechanical Action (TMA®) brings safe, easy, and cost-effective treatments for skin rejuvenation and dry eye care.

No light. No radiation. Just precise heat.

TMA® replaces laser energy with direct thermal contact—making treatments safer, gentler, and more comfortable for patients.

Thermo-Mechanical Contact

A matrix of heated titanium micro-pyramids briefly touches the skin, transferring precise thermal energy through controlled mechanical motion.

Targeted Thermal Effect

Each contact lasts only milliseconds, creating uniform micro-coagulation points that trigger natural renewal—without burning or ablation.

Safe, Efficient & Comfortable

The TMA® process uses conduction (not light), self-sterilizing pyramids, and lower total energy—delivering effective results with minimal discomfort or downtime.

Read our clinical publications

Tixel TMA® Products

A versatile portfolio powered by Thermo-Mechanical Action, designed to fit the needs and workflows of your practice.

Tixel i

2-Minute Dry-Eye Treatments.

Tixel i freestanding device

Tixel 2

Dual-Handpiece Time-Saving Versatility for Aesthetics.

Tixel 2 freestanding device

Tixel C

All-In-One, Compact Skin Rejuvenation.

Tixel C freestanding device

Clinical evidence

Peer-reviewed research and articles supporting TMA® technology

Peer-Reviewed Paper

The Efficacy of Thermal Mechanical Fractional Injury System for Facial Rejuvenation: Subjective, Objective and Image Analysis Study

February 24, 2025

PubMed

Guy Erlich, Ron Skorochod, Edmond Sabo, Rishi Saigal, Eliran Dahan, Yoram Wolf

Peer-Reviewed Paper

Safety and Effectiveness of a Thermo-Mechanical Fractional System at Low Settings for the Treatment of Photodamage

February 10, 2025

PubMed

Eric F Bernstein, Maggie Wang, Jennifer Wang, J Lee Pannell

Peer-Reviewed Paper

Percutaneous Delivery of Liquid Tetracycline Using a Thermal Resurfacing Drug Delivery System for the Treatment of Festoons

April 11, 2024

PubMed

Margarita Safir, Inbar Waizer, Ari Safir, Morris E Hartstein, Ofir Artzi

Peer-Reviewed Paper

Thermomechanical Fractional Injury Therapy Delivers Satisfactory Results, Less Pain With Surface Anesthesia

April 30, 2024

Medscape

Richard Mark Kirkner

Peer-Reviewed Paper

Frontal Fibrosing Alopecia-Related Facial Papules Successfully Treated With a Thermomechanical Fractional Injury Device

April 18, 2024

PubMed

Taciana Dal'Forno, Martina Souilljee Birck

Peer-Reviewed Paper

Effectiveness and Safety of a Thermo-Mechanical Action Device Versus Thermal Pulsation Device in the Treatment of Meibomian Gland Dysfunction

April 18, 2024

PubMed

E Sadri, A Verachtert, G D Parkhurst, J Echegoyen, I Klein, Y G Agmon, G J Berdy

Peer-Reviewed Paper

Safety and Efficacy of a Thermomechanical Fractional Injury Device for Periorbital Rhytides

February 22, 2023

PubMed

Jordan V Wang, Shirin Bajaj, David Orbuch, Moshe Lapidoth, Ifat Klein, Yael Agmon Gerste

Peer-Reviewed Paper

Prospective Evaluation of the Safety and Efficacy of Thermomechanical Fractional Injury for Perioral Rhytides

March 16, 2023

PubMed

Jordan V Wang, Shirin Bajaj, Alexa Steuer, David Orbuch, Roy G Geronemus

Peer-Reviewed Paper

Comprehensive Review of Thermomechanical Fractional Injury Device: Applications in Medical and Cosmetic Dermatology

February 17, 2024

PubMed

Blanca Estupiñan, Adam Souchik, Alexandra Kiszluk, Shraddha Desai

Peer-Reviewed Paper

Impact of Thermo-Mechanical Skin Treatment on Refraction and Keratometry in Patients with Dry Eye Disease and the Implications for Cataract Surgery

April 8, 2024

PubMed

Marta Blanco-Vázquez, Raquel Gil-Cazorla, Ankur Barua, Mukesh Taneja, Ludger Hanneken, Sunil Shah

Peer-Reviewed Paper

The Effect of Non-Ablative Thermomechanical Skin Treatment (Tixel®) on Dry Eye Disease: A Prospective Two-Centre Open-Label Trial

January 10, 2023

PubMed

Sunil Shah, Debarun Dutta, Ankur Barua, Ludger Hanneken, Shehzad A Naroo

Peer-Reviewed Paper

The Effect of Thermo-Mechanical Device (Tixel) Treatment on Evaporative Dry Eye Disease: A Pilot Prospective Clinical Trial

July 18, 2022

PubMed

M Safir, I Hecht, A Ahimor, S Zmujack-Yehiam, R Stein, E Bakshi, A Einan-Lifshitz 2, M E Hartstein

Peer-Reviewed Paper

Efficacy and Safety of a Thermal Fractional Skin Rejuvenation System (Tixel) for the Treatment of Facial and/or Scalp Actinic Keratoses

April 12, 2022

PubMed

Shabtai, Sloutsky, Lapidoth, Mimouni, Chorny, Snast, Leshem, Friedland, Hodak, Klein, Agmon, Levi

Peer-Reviewed Paper

Efficacy and safety of thermomechanical fractional injury‐assisted corticosteroid delivery versus intralesional corticosteroid injection for the tre..

December 16, 2021

PubMed

W Manuskiatti, C Yan, O Artzi, M K R Gervasio, R Wanitphakdeedecha

Peer-Reviewed Paper

Retrospective Study on the Safety and Tolerability of Clinical Treatments with a Novel Thermomechanical Ablation Device on 150 Patients

June 6, 2021

PubMed

Harryono Judodihardjo, Sajjad Rajpar

Peer-Reviewed Paper

Treatment of Periorbital Wrinkles Using Thermo-Mechanical Fractional Injury Therapy Versus Fractional Non-Ablative 1565 nm Laser: A Comparative Study

November 17, 2021

PubMed

Fares Salameh, Danny Daniely, Arielle Kauvar, Rafael L Carasso, Joseph N Mehrabi, Ofir Artzi

Peer-Reviewed Paper

Thermo‐Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double‐Center Chart Review

March 2, 2020

PubMed

Danny Daniely, Harryono Judodihardjo, Sajjad F Rajpar, Joseph N Mehrabi, Ofir Artzi

Peer-Reviewed Paper

Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epidermis‐ Protoporphyrin IX Fluorescence: Comparison of 5‐Aminolevulinic Acid ..

October 1, 2020

PubMed

C Foged, M Haedersdal, L Bik, C Dierickx, P A Phillipsen, K Togsverd-Bo

Peer-Reviewed Paper

Wound Healing Process After Thermomechanical Skin Ablation

January 13, 2020

PubMed

G Kokolakis, L von Grawert, M Ulrich, J Lademann, T Zuberbier, M Hofmann

Peer-Reviewed Paper

Enhanced Percutaneous Delivery of Beta-Blockers Using Thermal Resurfacing Drug Delivery System for Topical Treatment of Infantile Hemangiomas

July 10, 2020

PubMed

Jacob Mashiah, Efrat Bar-Ilan, Amir Koren, Or Friedman, Eyal Zur, Ofir Artzi

Peer-Reviewed Paper

Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients

April 9, 2020

PubMed

Y Hilerowicz, O Friedman, E Zur, R Ziv, A Koren, F Salameh, J N Mehrabi, O Artzi

Peer-Reviewed Paper

An Enhanced Transcutaneous Delivery of Botulinum Toxin for the Treatment of Hailey-Hailey Disease

December 27, 2019

PubMed

Efrat Bar-Ilan, Amir Koren, Wasim Shehadeh, Jacob Mashiah, Eli Sprecher, Ofir Artzi

Peer-Reviewed Paper

A New Method for Percutaneous Drug Delivery by Thermo-Mechanical Fractional Injury

June 28, 2019

PubMed

Ronen Shavit, Christine Dierickx

Peer-Reviewed Paper

A New Approach in the Treatment of Pediatric Hypertrophic Burn Scars: Tixel-Associated Topical Triamcinolone Acetonide and 5-Fluorouracil Delivery

January 20, 2020

PubMed

Ofir Artzi, Amir Koren, Roni Niv, Joseph N Mehrabi, Jacob Mashiah, Or Friedman

Peer-Reviewed Paper

The Scar Bane, Without the Pain: A New Approach in the Treatment of Elevated Scars: Thermomechanical Delivery of Topical Triamcinolone Acetonide and 5..

April 30, 2019

PubMed

Ofir Artzi, Amir Koren, Roni Niv, Joseph N. Mehrabi, Or Friedman

Peer-Reviewed Paper

Treatment of Port Wine Stain with Tixel-Induced Rapamycin Delivery Following Pulsed Dye Laser Application

December 4, 2019

PubMed

Ofir Artzi, Jos N. Mehrabi, Lee Heyman, Or Friedman, Jacob Mashiah

Peer-Reviewed Paper

The Toxic Edge: A Novel Treatment for Refractory Erythema and Flushing of Rosacea

October 12, 2018

PubMed

Or Friedman, Amir Koren, Roni Niv, Joseph N. Mehrabi, Ofir Artzi

Peer-Reviewed Paper

A Novel Thermo-Mechanical System Enhanced Transdermal Delivery of Hydrophilic Active Agents by Fractional Ablation

June 29, 2019

PubMed

Amnon C. Sintov, Maja A. Hofmann

Peer-Reviewed Paper

Fractional Treatment of Aging Skin with Tixel: A Clinical and Histological Evaluation

January 20, 2016

PubMed

Monica Elman, Nathalie Fournier, Gilbert Barnéon, Eric F. Bernstein, Gary Lask

Peer-Reviewed Paper

Fractional Vaporization of Tissue with an Oscillatory Array of High Temperature Rods: Part I: Ex Vivo Study

October 14, 2012

PubMed

Gary Lask, Monica Elman, Nathalie Fournier, Michael Slatkine

Browse all publications

Technology Deep Dive

The details of TMA

What TMA is

TMA® (Thermo-Mechanical Action) is Tixel's proprietary, non-laser fractional technology that delivers controlled thermal energy to tissue through direct contact. Instead of relying on light (and radiation), TMA® combines precision motion with heat conduction via a medical-grade titanium tip.

At the core of the system is a 1 cm2 treatment array made of tiny, pyramid-shaped pins manufactured from biocompatible materials. The pins are heated to 400°C and are self-sterilized.

How energy is delivered

During treatment, the pin matrix is introduced to the skin surface at a precisely controlled speed, creating very brief contact—on the order of milliseconds. This short, repeatable contact time enables the thermal energy stored in the pins to be transferred rapidly and consistently into superficial tissue.

The thermal effect in tissue

The conductive heat transfer creates an array of tiny, non-ablative coagulation sites. A key safety characteristic of the mechanism is that each pyramid pin holds a limited amount of energy. This constrains peak heat delivery at each contact point and helps prevent burns and tissue charring.

Why comfort is relatively high

Pain during Tixel treatment is generally lower than with an ablative CO₂ laser primarily because less energy is transferred to the skin and the transfer method is more efficient:

  • Conduction vs. radiation: TMA® transfers heat by direct contact (conduction), rather than delivering energy through light (radiation).
  • Longer pulse duration: Tixel typically uses a longer pulse duration (for example, 10 ms vs. 1 ms with CO₂ lasers), which can reduce peak intensity and improve tolerability.

Enhanced skin permeability: what research suggests

Research indicates that TMA® can create superficial micro-channels in the stratum corneum, potentially increasing permeability for topically applied hydrophilic substances used after treatment.

Important note

Tixel's intended use does not currently include tissue permeability enhancement.

Let us give you a demo

Schedule a personalized walkthrough of TMA® technology with our product specialists. We'll follow up by email to coordinate your preferred timeframe and location.

What to expect
  • Guided walkthrough of TMA® technology
  • Live Q&A with a specialist
  • Pricing and implementation guidance
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Discover Tixel® powered by TMA® technology. Revolutionary fractional skin resurfacing with maximum safety, minimal side effects. Quick, effective treatments for aesthetic and dry eye applications.

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